Different decay of antibody response and VOC sensitivity in naïve and previously infected subjects at 15 weeks following vaccination with BNT162b2

Published: 3 February 2022| Version 1 | DOI: 10.17632/2kff23dc36.1


The associate DOI for this manuscript is: https://doi.org/10.1186/s12967-021-03208-3 Published in 2022 by Lucia Lopalco et al. Twenty-six naïve and 9 previously SARS-CoV-2 infected subjects during the second wave of the pandemic in Italy were enrolled for this study. The two groups had comparable demographic and clinical characteristics. By means of ELISA and pseudotyped-neutralization assays, we investigated the kinetics of developed IgG-RBD and their neutralizing activity against both the ancestral D614G and the SARS-CoV-2 variants of concern emerged later, respectively. Although after 15 weeks from vaccination IgG-RBD dropped in all participants, naïve subjects experienced a more dramatic decline than those with previous SARS-CoV-2 infection. Neutralizing antibodies remained higher in subjects with SARS-CoV-2 history and conferred broad-spectrum protection. A table including all clinical data, ELISA and Neutralization assay is attached here (named Vaccinated + Neut + ELISA)



Ospedale San Raffaele


Antibody, Neutralization, COVID-19