High sensitivity of ROSE-supported ERCP-guided brushing on biliary strictures

Published: 11 February 2022| Version 1 | DOI: 10.17632/433mk4hmsy.1
, Alberto Mariani, Biagio Ciambriello, Maria Chiara Petrone, Gemma Rossi, Sabrina Gloria Giulia Testoni, Michele Carlucci, Luca Aldrighetti, Massimo Falconi, Gianpaolo Balzano, Claudio Doglioni, Gabriele Capurso, Paolo Giorgio Arcidiacono


Endoscopic Retrograde CholangioPancreatography (ERCP) plays a major role in biliary strictures, with brushing being a cheap and fast method to acquire cytological specimen, despite a sensitivity around 45%. Rapid On-Site Evaluation (ROSE) is widely used for Endoscopic Ultrasound-acquired cytological specimen adequacy, improving its sensitivity and specificity, nevertheless, no study evaluated its role for ERCP-guided brushing. Our aim was to assess the diagnostic yield of ERCP-guided brushing of biliary strictures when supported by ROSE. This is the database from a retrospective single-center study, including patients undergoing ERCP-guided brush cytology supported by ROSE for biliary strictures. Recorded data included patient’s clinical-radiological and ERCP features. Final diagnosis was determined after surgery, intraductal biopsy or adequate follow-up. The diagnostic yield was calculated and a subgroup analysis for factors associated with false negative or true positive result was performed. This is the first study evaluating the use of ROSE as support for ERCP-guided brushing of biliary strictures, with a sensitivity far higher than those reported for brushing alone, and at least comparable to those of more expensive and invasive techniques.


Steps to reproduce

All data are explained in article with doi: 10.1055/a-1322-2638.


Ospedale San Raffaele


Pancreatic Cancer, Biliary Tree Tumor, Ercp