The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with chemokine CXCL12
Description
The file contains source data on HMGB1-CXCL12 interaction. Data contain: Data contain: Figure 2: data generating bar graphs displayed in b-k Figure 3: data generating bar graphs displayed in c-g Figure 4: data generating bar graphs displayed in c-f Figure 5: ITC sequential pulses displayed in Figure 5a-c, normalized MST signals displayed in Figure d,e Figure 6: SV-AUC data displayed in a-c, MS-SV analysis displayed in f Figure 7:SAXS data displayed in a-d Figure 8:Quantification of PLA signals displayed in a-c Supplementary S3: data generating bar graphs displayed in b-k Supplementary Figure S4:data generating bar graphs displayed in b-d; normalized M ST signals displayed in e Supplementary Figure S6: ITC sequential pulses displayed in c,d Supplementary Figure S7:SV-AUC data displayed in a-j, MS-SV analysis displayed in k. Supplementary Figure S8: SAXS data displayed in Figure a,b Supplementary Figure S9: HMGB1 SAXS dilution series displayed in a-c Supplementary Figure S10: CXCL12 SAXS dilution series displayed in a-c Supplementary Figure S11 SAXS data and EOM analysis displayed in a and b Figure S12: SAXS concnetration series of frHMGB1 titrated with CXCL12 a-b Figure S13: Supplementary Figure S12: Fits to SAXS data of the a) SASREF and b)F oXSDock model of frHMGB1-CXCL12 complex Figure S14: Quantification of PLA displayed in b Figure S15:FAXS analysis displayed in c In SourceDATA/excel all sourcedata in excel format
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Institutions
- IRCCS Ospedale San RaffaeleLombardy, Milan
Categories
Funders
- Fondazione AIRC per la ricerca sul cancro ETSLombardy, ItalyGrant ID: IG21440