IL-10-producing regulatory cells impact on Celiac Disease evolution

Published: 8 February 2024| Version 1 | DOI: 10.17632/nhzr85fts6.1
Contributors:
,
, Virginia Bassi, Serena Vitale, Ilaria Mottola, Marina Di Stefano, Lorella Fanti, Paola Sgaramella, Chiara Ziparo, Silvia Furio, Renata Auricchio, Graziano Barera, Giovanni Di Nardo, Riccardo Troncone, Carmen Gianfrani,

Description

In the manuscript "IL-10-producing regulatory cells impact on celiac disease evolution" (doi: 10.1016/j.clim.2024.109923), we showed that IL-10-producing cells are fundamental in controlling pathological T-cell responses to gluten. In brief, our major findings are: 1) Gluten ingestion induces systemic inflammation in CD patients; 2) Gliadin-specific IFN-g+ T cells are present in patients regardless of tissue damage; 3) The presence of DC-10 in mucosal infiltrates is a hallmark of potential CD patients; 4) In potential CD, DC-10 maintain mucosal homeostasis and protect the gut from damage. The datasets here loaded contain all the clinical and immunological data, supporting our conclusions, that have been used to build the manuscript. An additional file (raw_data_description) contains the main guidelines to correctly associate the raw data with the corresponding figure/table in the manuscript.

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Institutions

Universita degli Studi di Roma La Sapienza, Ospedale San Raffaele, Universita degli Studi di Napoli Federico II

Categories

Dendritic Cell, Celiac Disease, Regulatory T Cell, Interleukin-10 Family

Funding

Fondazione Telethon

TeleG1 2016-2021 to SG

Ministero della Salute

RF-2016-02361372 to SG

Related Links

Article
https://www.sciencedirect.com/science/article/pii/S1521661624000342
is related to this dataset

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