IL-10-producing regulatory cells impact on Celiac Disease evolution
In the manuscript "IL-10-producing regulatory cells impact on celiac disease evolution" (doi: 10.1016/j.clim.2024.109923), we showed that IL-10-producing cells are fundamental in controlling pathological T-cell responses to gluten. In brief, our major findings are: 1) Gluten ingestion induces systemic inflammation in CD patients; 2) Gliadin-specific IFN-g+ T cells are present in patients regardless of tissue damage; 3) The presence of DC-10 in mucosal infiltrates is a hallmark of potential CD patients; 4) In potential CD, DC-10 maintain mucosal homeostasis and protect the gut from damage. The datasets here loaded contain all the clinical and immunological data, supporting our conclusions, that have been used to build the manuscript. An additional file (raw_data_description) contains the main guidelines to correctly associate the raw data with the corresponding figure/table in the manuscript.
TeleG1 2016-2021 to SG
Ministero della Salute
RF-2016-02361372 to SG