Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases

Published: 26 June 2023| Version 1 | DOI: 10.17632/nkvffj37z4.1
Contributors:
Laura Passeri, Grazia Andolfi, Virginia Bassi, Fabio Russo, Giorgia Giacomini, Cecilia Laudisa, Ilaria Marrocco, Luca Cesana, Marina Di Stefano, Lorella Fanti, Paola Sgaramella, Serena Vitale, Chiara Ziparo, Renata Auricchio, Graziano Barera, Giovanni Di Nardo, Riccardo Trocone, Carmen Gianfrani, Andrea Annoni, Laura Passerini, Silvia Gregori

Description

In the manuscript "Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases" published in Journal of Autoimmunity on May 22 2023 (doi: 10.1016/j.jaut.2023.103051). We describe the in vitro generation of dendritic cells genetically modified to render them pro-tolerogenic and able to modulate unwanted immune responses to auto-antigens both in vitro and in vivo. Raw data for each main figure published in the manuscript are available in the relative.csv file. Read the Read_me.rtf file for more details and for the accession numbers of NGS data deposited at GEO.

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Institutions

San Raffaele Telethon Institute for Gene Therapy, Universita degli Studi di Roma La Sapienza, Ospedale San Raffaele, Consiglio Nazionale delle Ricerche, Universita degli Studi di Napoli Federico II

Categories

Autoimmunity, Type 1 Diabetes, Immune Regulation, Celiac Disease, Dendritic Cell Immunotherapy, Dendritic Cell Therapy, Human T Regulatory Cell, Interleukin-10 Family, Immunological Tolerance

Funding

Ministero della Salute

RF-2016-02361372

Fondazione Telethon

TeleG1

Licence