Association between CKD and frailty in the FRASNET study
Description
The dataset includes the row data shown in Tables 1-2 and in graph in Figure 1 of the paper: Lanzani C, Citterio L, Concas MP, Barruscotti A, Zagato L, Simonini M, Brioni E, El Boustani M, Damanti S, Rovere-Querini P, Manfredi AA, Manunta P. The association between CKD and frailty in the FRASNET study: suggestion of a novel eGFR threshold as a key determinant of frailty in the elderly. Journal of Nephrology 2025. doi: 10.1007/s40620-025-02442-y This study deals with frailty, a geriatric syndrome marked by reduced physiological reserves, linked to organ dysfunction. However, the specific contribution of kidney function to frailty remains underexplored. The aim is to assess the impact of kidney function on frailty in a large population of older adults. The FRASNET (Frailty and Sarcopenia Network) cohort included 1183 individuals (59.9% females, age 65–93). Among them, 27.7% of subjects were classified as robust, 37.6% were pre-frail, and 34.7% were frail. The prevalence of frailty increased with age (43% in individuals over 76 years of age) and was associated with obesity (28.3%) and polytherapy (23.2%). Whole estimated glomerular filtration rate (eGFR) was 73.8 (IQR 62.4, 84.7) ml/min/1.73 m2. The prevalence of chronic kidney disease (CKD) increased across frailty classes from 15.2% in robust to 29.0% in frail individuals (P < 0.001). Among young-old subjects (65–75 years old), comorbidity was the main determinant of frailty, whereas in older subjects, when eGFR was below 53.5 ml/min/1.73 m2, it was associated with frailty (P < 0.002). Fractional excretion of sodium progressively increased across frailty classes, from 0.71% in robust individuals (IQR 0.46–1.03) to 0.79% in frail subjects (IQR 0.48–1.17) (P = 0.04). This study revealed a strong relationship between CKD and frailty, identifying a new eGFR threshold associated with frailty in older adults, thus highlighting the potential role of the often-overlooked tubular function in older individuals.