A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

Published: 11 February 2022| Version 1 | DOI: 10.17632/xrsst4nd97.1
, Francesco Cilenti, Giulia Barbiera, Marco Genua


Prostaglandin E2 (PGE2) modulates macrophage activation during homeostasis and disease, but the underlying mechanisms remain incompletely characterized. Cilenti, Barbiera, et al. reveal that PGE2 suppresses inflammatory gene expression by targeting a set of inflammatory gene enhancers marked by MEF2A, a critical regulator of type I interferon induction. DOI: https://doi.org/10.1016/j.immuni.2021.05.016 Raw and analyzed RNA-Seq data: This paper, ArrayExpress: E-MATB-9275 Raw and analyzed scRNA-Seq data: This paper, ArrayExpress: E-MATB-9253 Raw and analyzed ChIP-Seq data: This paper, ArrayExpress: E-MATB-9254 Raw and analyzed ATAC-Seq data: This paper, ArrayExpress: E-MATB-9252



Ospedale San Raffaele


Interferon, Macrophage, Innate Immunity