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  • Original data: "The interaction of the tumor suppressor FAM46C with p62 and FNDC3 proteins integrates protein and secretory homeostasis". Fucci et al. Cell Reports 2020
    Raw data and original images: "The interaction of the tumor suppressor FAM46C with p62 and FNDC3 proteins integrates protein and secretory homeostasis" Fucci et al. Cell Reports 2020. Descriptions of data and methods are included in the Cell Reports manuscript. RAW files generating Datasets 1-3 in the manuscript are present in the Proteomics folder. Raw data/original images are organized according to the associated figure panel.
    • Other
    • Slides
    • Software/Code
    • Image
    • Tabular Data
    • Dataset
    • Document
    • Text
  • Data for: Biomarkers of DNA damage in COPD patients undergoing pulmonary rehabilitation: Integrating clinical parameters with genomic profiling
    The file attached is the .sav file which has been used for all statistical analyses with the SPSS software. The description of all variables is reported in the file description sheet. We are available to help with the undesrtanding of data structure
    • Software/Code
    • Dataset
  • Data for Zuliani et al
    Subject-wise datset.
    • Tabular Data
    • Dataset
  • Data for: Mid-term outcomes after percutaneous interventions in coronary bifurcations
    The Excel data sheet enlists data from 5,036 consecutive patients who underwent percutaneous coronary intervention with drug-eluting stent on coronary bifurcation at 17 major coronary intervention centers between January 2012 and December 2014.
    • Tabular Data
    • Dataset
  • Three-dimensional Human iPSC-derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering
    Raw data of Maffioletti SM, Sarcar S et al., Cell Reports 2018
    • Dataset
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  • GMXPBSA 2.1: A GROMACS tool to perform MM/PBSA and computational alanine scanning
    This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018) Abstract GMXPBSA 2.1 is a user-friendly suite of Bash/Perl scripts for streamlining MM/PBSA calculations on structural ensembles derived from GROMACS trajectories, to automatically calculate binding free energies for protein–protein or ligand–protein complexes [R.T. Bradshaw et al., Protein Eng. Des. Sel. 24 (2011) 197–207]. GMXPBSA 2.1 is flexible and can easily be customized to specific needs and it is an improvement of the previous GMXPBSA 2.0 [C. Paissoni et al., Comput. Phys. Commun. (2014), 185,... Title of program: GMXPBSA 2.1 Catalogue Id: AETQ_v1_1 Nature of problem Calculates the Molecular Mechanics (MM) data (Lennard-Jones and Coulomb terms) and the solvation energy terms (polar and nonpolar terms respectively) from an ensemble of structures derived from GROMACS molecular dynamics simulation trajectory. These calculations are performed for each single component of the simulated complex, including protein and ligand. In order to cancel out artefacts an identical grid setup for each component, including complex, protein and ligand, is required. Performs sta ... Versions of this program held in the CPC repository in Mendeley Data AETQ_v1_0; GMXPBSA 2.0; 10.1016/j.cpc.2014.06.019 AETQ_v1_1; GMXPBSA 2.1; 10.1016/j.cpc.2014.09.010
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  • GMXPBSA 2.0: A GROMACS tool to perform MM/PBSA and computational alanine scanning
    This program has been imported from the CPC Program Library held at Queen's University Belfast (1969-2018) Abstract GMXPBSA 2.0 is a user-friendly suite of Bash/Perl scripts for streamlining MM/PBSA calculations on structural ensembles derived from GROMACS trajectories, to automatically calculate binding free energies for protein–protein or ligand–protein complexes. GMXPBSA 2.0 is flexible and can easily be customized to specific needs. Additionally, it performs computational alanine scanning (CAS) to study the effects of ligand and/or receptor alanine mutations on the free energy of binding. Calculations ... Title of program: GMXPBSA 2.0 Catalogue Id: AETQ_v1_0 Nature of problem Calculates the Molecular Mechanics (MM) data (Lennard-Jones and Coulomb terms) and the solvation energy terms (polar and nonpolar terms respectively) from an ensemble of structures derived from GROMACS molecular dynamics simulation trajectory. These calculations are performed for each single component of the simulated complex, including protein and ligand. In order to cancel out artefacts an identical grid setup for each component, including complex, protein and ligand, is required. Performs sta ... Versions of this program held in the CPC repository in Mendeley Data AETQ_v1_0; GMXPBSA 2.0; 10.1016/j.cpc.2014.06.019 AETQ_v1_1; GMXPBSA 2.1; 10.1016/j.cpc.2014.09.010
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  • Dataset related to article "Prevalence of Taste and Smell Dysfunction in Coronavirus Disease 2019"
    This record contains raw data related to article “Prevalence of Taste and Smell Dysfunction in Coronavirus Disease 2019" Importance: Early diagnosis of coronavirus disease 2019 (COVID-19) may help control the diffusion of the disease into the population. Objective: To investigate the presence of sinonasal manifestations at the onset of COVID-19 to achieve an earlier diagnosis. Design, setting, and participants: This retrospective telephone survey study investigated patients diagnosed with COVID-19 from March 5 to March 23, 2020, who were hospitalized or discharged from a single referral center. Patients who were unable to answer (intubated, receiving noninvasive ventilation, or deceased) or unreachable by telephone were excluded. Of 359 consecutive patients, 204 fulfilled the inclusion criteria; 76 were unable to answer, 76 were unreachable by telephone, and 3 refused. Exposures: Sinonasal manifestations reported before COVID-19 diagnosis were studied with a validated questionnaire: Italian Sino-Nasal Outcome Test 22 (I-SNOT-22). If reduction of taste and/or smell was documented by item 5 of the I-SNOT-22, further inquiries were made to score them separately on a scale from 0 to 5, with 0 indicating no problem and 5 indicating problem as bad as it can be. Main outcomes and measures: The prevalence of sinonasal manifestations preceding COVID-19 diagnosis. Results: Among the 204 patients enrolled (110 [53.9%] male; mean [SD] age, 52.6 [14.4] years), the median I-SNOT-22 total score was 21 (range, 0-73). I-SNOT-22 identified 116 patients (56.9%) with reduction of taste and/or smell, 113 (55.4%) with taste reduction (median score, 5; range, 2-5), and 85 (41.7%) with smell reduction (median score, 5; range, 1-5). Eighty-two patients (40.2%) reported both. Severe reduction of taste was present in 81 patients (39.7%), and severe reduction of smell was present in 72 patients (35.3%). Only 12 patients (14.8%) with severe taste reduction and 12 patients (16.7%) with severe smell reduction reported severe nasal obstruction. Severe reduction of taste and smell was more prevalent in female vs male patients (odds ratios, 3.16 [95% CI, 1.76-5.67] vs 2.58 [95% CI, 1.43-4.65]) and middle-aged vs younger patients (effect sizes, 0.50 [95% CI, 0.21-0.78] vs 0.85 [95% CI, 0.55-1.15]). No significant association was observed between smoking habits and severe reduction of taste (odds ratio, 0.95; 95% CI, 0.53-1.71) and/or smell (odds ratio, 0.65; 95% CI, 0.35-1.21). Conclusions and relevance: The findings of this telephone survey study suggest that reduction of taste and/or smell may be a frequent and early symptom of COVID-19. Nasal obstruction was not commonly present at the onset of the disease in this study. The general practitioner may play a pivotal role in identifying potential COVID-19 in patients at an early stage if taste and/or smell alterations manifest and in suggesting quarantine before confirmation or exclusion of the diagnosis.
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  • Data related to article "ATPase Domain AFG3L2 Mutations Alter OPA1 Processing and Cause Optic Neuropathy"
    Functional studies in a yeast model and patient-derived fibroblast cell lines
    • Dataset
  • data related to article "Generation of a human iPSC line, FINCBi001-A, carrying a homoplasmic m.G3460A mutation in MT-ND1 associated with Leber's Hereditary Optic Neuropathy (LHON)"
    genetic analysis related to article "Generation of a human iPSC line, FINCBi001-A, carrying a homoplasmic m.G3460A mutation in MT-ND1 associated with Leber’s Hereditary Optic Neuropathy (LHON)"
    • Dataset
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