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  • Malnutrition in SARS-CoV-2 infected patients
    An outbreak of viral pneumonia was reported in Wuhan, China, at the end of December 2019, and subsequent sample analyses discovered the involvement of a new strain of coronavirus (SARS-CoV-2), which belongs to the same family of single-stranded enveloped RNA viruses that caused the emergences of SARS-CoV in 2003 and MERS-CoV in 2012. Symptoms of COVID-19 (SARS-CoV-2 syndrome) may occur within 2–14 days after exposure and can lead to difficulties in cilium beating of airway cells and to alveolar damage. Infected patients experience mild to severe manifestations, such as fever, dry cough, dyspnoea, abdominal pain, and diarrhea. Most cases resolve rapidly, but the infection can still be fatal in about 3% of cases. Much like MERS or the coronavirus that infects pigs, the enteric affections can be prominent, possibly leading to the loss of absorptive potential. Just a few weeks after its discovery, the COVID-19 has been considered a serious worldwide threat. Preliminary data suggest that male older adults and subjects with immune dysfunctions might be more susceptible to the worse viral disease, but there is a need to further investigate the virulence factors. One of the factors most discussed is the malnutritional status of the host, but most of the beliefs are anecdotal. The dataset was used to write the article "The Malnutritional Status of the Host as a Virulence Factor for New Coronavirus SARS-CoV-2", which was published by the Journal Frontiers in Medicine in 2020.
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  • Host dysosmia in SARS-CoV-2 infection
    The respiratory condition COVID-19 arises in a human host upon the infection with SARS-CoV-2, a coronavirus that was first acknowledged in Wuhan, China, at the end of December 2019 after its outbreak of viral pneumonia. The full-blown COVID-19 can lead, in susceptible individuals, to premature death because of the massive viral proliferation, hypoxia, misdirected host immunoresponse, microthrombosis, and drug toxicities. Alike other coronaviruses, SARS-CoV-2 has a neuroinvasive potential, which may be associated with early neurological symptoms. In the past, the nervous tissue of patients infected with other coronaviruses was shown to be heavily infiltrated. Patients with SARS-CoV-2 commonly report dysosmia, which has been related to the viral access in the olfactory bulb. However, this early symptom may reflect the nasal proliferation that should not be confused with the viral access in the central nervous system of the host, which can instead be allowed by means of other routes for spreading in most of the neuroanatomical districts. The dataset was used to write the hypothesis "Disentangling the Hypothesis of Host Dysosmia and SARS-CoV-2: The Bait Symptom That Hides Neglected Neurophysiological Routes", which was published by the Journal Frontiers in Physiology in 2020.
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  • COVID-19 isolation and frailty
    In the post-COVID-19 era, the saturation of health services may only be the tip of the iceberg in relation to the restriction-derived burden of frailty. During confinement, the diminished state of resilience in elderly people may have worsened all age-associated conditions, such as a mild high blood pressure, glucose intolerance, basal immune dysfunction, inflammaging, and mental liability with anxiety-depressive traits. The dynamics of “frailty” renders its transition to a worse level more common than improvement, and this COVID-19 pandemic may have spin the loop of a decline of decreasing functional ability, increasing frailty, greater risk of traumatic falls, and higher hospital admissions for fragility fractures in the near future. The dataset was used to write the opinion article "Consequences for the Elderly After COVID-19 Isolation: FEaR (Frail Elderly amid Restrictions)", which was published by the Journal Frontiers in Psychology in 2020. It has been also used for the research article "How SARS-CoV-2 Pandemic Changed Traumatology and Hospital Setting: An Analysis of 498 Fractured Patients", published in 2021 by the Journal of Clinical Medicine.
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  • Study of Ras Mutations’ Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis
    Cancers (Basel). 2020 Jul; 12(7): 1919. Published online 2020 Jul 16. doi: 10.3390/cancers12071919 Background: Colorectal cancer (CRC) is the second most common cause of cancer-specific death in both sexes in Western countries. KRAS mutations occur in about 50% of metastatic CRCs (mCRCs). The prognostic value of specific KRAS mutations still remains unexplored and unclear. Methods: Two hundred and forty KRAS wild-type and 206 KRAS/NRAS mutant consecutive unresectable mCRC patients with PS Eastern Cooperative Oncology Group (ECOG) 0 or 1, aged 3 months entered into this study. DNA was extracted from paraffin-embedded formalin-fixed tumour tissues, and it was sequenced with the Oncomine Solid Tumour DNA kit (Thermo Fisher Scientific, Waltham, MA, USA). Data were analysed using the Torrent Suite Software v5.0 (Thermo Fisher Scientific). The primary outcome was the analysis of the prognostic role of different KRAS mutations in terms of overall survival (OS). Results: There were no significant differences among the most prevalent mutations (p.G12D, p.G12V, p.G13D, p.G12A, p.G12C, and p.G12S) in terms of age (<65 vs. ≥65 years), gender (male vs. female), grading (G1/G2 vs. G3), side of primary tumour (left vs. right), pT, and pN. At the median follow-up of 25.6 months, there were 77 deaths in KRAS-mutated patients and 94 in wild-type patients. Three homogeneous prognostic groups were identified: wild-type patients (group A, median survival: 27.5 months), p.G13D/p.G12A/p.G12V/p.G12D mutants (group B, median survival: 17.3 months), and p.G12C/p.G12S mutants (group C, median survival: 5.0 months, p < 0.0001 according to Log Rank test). Upon multivariate analysis, metastatic involvement and p.G12C/p.G12S KRAS mutation group C (vs. other mutations) emerged as independent prognostic variables for survival. Conclusions: We show that mutant KRAS is a negative prognostic factor and that p.G12C/p.G12S variants present the worst clinical courses. This information suggests a clear difference among KRAS mutations, and it will be useful to test potentiated and/or innovative therapeutic strategies in p.G12C/p.G12S metastatic CRC patients.
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  • DATABASE_RF-2011-02351933
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  • rs-fMRI network-based TMS targeting
    The present data are collected from 8 Alzheimer's disease patients to prove the feasibility of a tailored network-based transcranial magnetic stimulation (TMS) targeting approach. Based on resting state functional imaging, the procedure allows to extract individual optimal targets of two networks affected by Alzheimer's disease: the default mode (DMN) and the fronto-parietal network (FPN). The dataset includes: - The raw independent components maps (melodic_IC.nii.gz) in native space extracted from individual rs-fMRI with Melodic independent component analysis (Beckman and Smith 2004) - A table with the demographic and clinical characteristics of the sample (n=8) together with the individual coordinates of the target in native space.
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  • Mother's empathy for pain hyperscanning
    The file reports data to calculate cortical activation of mothers (observing a heel prick performed on their newborn), newborns (experiencing the heel-prick) and cortical synchronization between activated areas in the dyad mother-newborn, by wavelet transform coherence (WTC) analysis.
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  • Brain MRS correlates with mitochondrial dysfunction biomarkers in MELAS-associated mtDNA mutations
    MR spectroscopy data related to the paper Brain MRS correlates with mitochondrialdysfunction biomarkers in MELAS-associated mtDNA mutations, Annals of Clinical and Translational Neurology, 2021 May 5. doi: 10.1002/acn3.51329
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  • Brain functional MRI responses to blue light stimulation in Leber's Hereditary Optic Neuropathy
    Input data for the statistical analysis related to the paper Brain functional MRI responses to blue light stimulation in Leber's Hereditary Optic Neuropathy. Biochem Pharmacol. 2021 Feb 26:114488. doi: 10.1016/j.bcp.2021.114488.
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  • Clinical Characteristics of Severe COVID-19 in Italy
    Italy was one of the worst affected European countries during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. More than 50% of Italian cases occurred in the northern region of Lombardy, where the saturation of health services between March and April 2020 forced hospitals to allocate patients according to available resources. Eighteen severe coronavirus disease 2019 (COVID-19) patients were admitted to our hospital needing intensive support. Given the disease fatality, we investigated the patients' characteristics to identify mortality predictors. We counted seven deaths from multiple organ failure, two from septic shock, and two from collapsed lungs. The maximum case fatality was observed in patients who contracted SARS-CoV-2 in hospitals. The fatal outcome was associated with the following baseline characteristics: polymorbidity (OR 2.519, p = 0.048), low body mass index (OR 2.288, p = 0.031), low hemoglobin (OR 3.012, p = 0.046), and antithrombin III (OR 1.172, p = 0.048), along with a worsening of PaO2/FiO2 ratio in the first 72 h after admission (OR 1.067, p = 0.031). The occurrence of co-infections during hospitalization was associated with a longer need for intensive care (B = 4.511, p = 0.001). The dataset was used to write the article "Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic", which was published by the Journal Frontiers in Medicine in 2021 (DOI:10.3389/fmed.2021.582896).
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