Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth

Description

These files contain the raw images and dataset used to generate Figures 1A, 5 (panels B, C, and G), 6 (panels A, D, E and F), and S3A of the article titled “Blockade of αvβ6 and αvβ8 integrins with a chromogranin A-derived peptide inhibits TGFβ activation in tumors and suppresses tumor growth” by A.M. Gasparri, A. Pocaterra, B. Colombo, G. Taiè, C. Gnasso, A. Gori, F. Pozzi, A. Smith, F. Magni, A. Ugolini, M. Doglio, M.C. Bonini, A. Mondino, A. Corti, and C. Curnis, published in J Exp Clin Cancer Res 44, 88 (2025). https://doi.org/10.1186/s13046-025-03352-4 The research leading to these findings was funded by Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG 2019 – ID. 23470 project – P.I. Angelo Corti; Fondazione AIRC 5 per Mille 2019 program (ID. 22737), P.I. MC Bonini, Group Leader A. Corti and A. Mondino; collectively supported by the national funding organizations under the framework of the ERA-NET TRANSCAN-3 initiative (ReachGlio project, ID: TRANSCAN2022-784-017 – Italian Ministry of Health ID: ERP-2022-23683648 to F. Curnis); and National Recovery and Resilience Plan (NRRP), M6/C2_CALL 2023 (project: POC-2023-12377318 to F. Curnis) funded by the European Union – NextGenerationEU.

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Funders

• Italian Association for Cancer Research

  Italy

  Grant ID: IG 2019
• AIRC 5 per Mille 2019 program

  Grant ID: ID. 22737
• ERA-NET TRANSCAN-3 initiative

  Grant ID: (ReachGlio project, ID: TRANSCAN2022-784-017 – Italian Ministry of Health ID: ERP-2022-23683648
• Ministero della Salute

  Italy

  Grant ID: National Recovery and Resilience Plan (NRRP), M6/C2_CALL 2023, project: POC-2023-12377318

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